activation
alzheimers disease
autoimmune disease
biochemistry
cancer
caspase
cell death
enzyme
immune system
immunology
inflammasome
inflammation
macromolecule
mitotic kinase
molecules
nek7
neurodegenerative disease
nrlp3
polypeptide
proinflammatory cytokine
protein
protein complex
protein domain
pyroptosis
定額
The mitotic kinase NEK7 binds to inactive NRLP3 leading to the assembly and activation of the NLRP3 inflammasome. From left to right: apo-NEK7 (inactive), active NEK7, NE7 bound to NLRP3. Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine maturation and cell death. Dysregulation of inflammation activation can lead to cancer, autoimmune and neurodegenerative diseases. Source: PDB entries 2WQM, 6NPYの素材 [FY310138339224]
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